Author

Florie Demiautte

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:rat· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Devrim KilinciD· 4 shared Jean‐Charles LambertiD· 4 shared Philippe AmouyeliD· 4 shared Julien ChapuisiD· 3 shared Tiago MendesiD· 3 shared Amandine Flaig· 2 shared Anaïs-Camille Vreulx· 2 shared Audrey CouloniD· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Devrim KilincORCID

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4 papers

Recent·Most cited

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire‐Regatillo, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Frank Lafont, Philippe Amouyel, K. Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki‐Wullich, , Pierre Dourlen

This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.

bioRxiv · Aug 11, 2025 · PreprintNeuroscience

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki‐Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Difan Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, , Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

bioRxiv · Apr 29, 2024 · PreprintNeuroscience

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaïs-Camille Vreulx, Amandine Flaig, Tiago Mendes, Sandrine Hughes, Benjamin Grenier‐Boley, Xavier Hanoulle, Florie Demiautte, Charlotte Bauer, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, , Julien Chapuis

The paper identifies FERMT2 as a key modulator of axon guidance and synaptic plasticity in an APP-dependent manner, linking its genetic risk variant to Alzheimer's disease through miRNA regulation.

Molecular Psychiatry · Nov 3, 2020Peer-reviewedNeuroscience

Pyk2 Overexpression in Postsynaptic Neurons Blocks Aβ1-42-induced Synaptotoxicity in a Microfluidic Co-Culture Model

Devrim Kilinc, Anaïs-Camille Vreulx, Tiago Mendes, Amandine Flaig, Diego Marques Coelho, Maxime Verschoore, Florie Demiautte, Philippe Amouyel, Neuro-CEB Brain Bank, Fanny Eysert, Pierre Dourlen, Julien Chapuis, Marcos R. Costa, Nicolas Malmanche, Frédéric Checler, Jean‐Charles Lambert

The paper develops a microfluidic co-culture model to study Aβ1-42-induced synaptotoxicity and shows Pyk2 overexpression in postsynaptic neurons protects against it.

bioRxiv · Dec 20, 2019 · PreprintNeuroscience