Kurt David Hankenson

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

This study investigates the acute effects of intra-articular IDO-1 liposomes after ACL injury, showing reduced tryptophan, inflammation markers, and altered T cell ratios, with increased cartilage thickness in rats.

This study shows that TSP2 deficiency leads to increased joint inflammation and worsened osteoarthritis after injury, suggesting TSP2's role in joint homeostasis.

This paper develops a sample processing pipeline for spatial transcriptomics of murine musculoskeletal tissues, achieving high-quality transcript detection across multiple tissue types using the Xenium Prime 5K platform.

The paper integrates GWAS data with a CRISPRi screen in osteoblasts to identify genes affecting bone mineral density and reveals pleiotropy across non-bone tissues.

This study shows that Rspo2 from gustatory neurons is essential for taste bud maintenance through genetic experiments in mice.

This study shows that CD47 inhibition impairs bone fracture healing by reducing mesenchymal stem cell proliferation, despite increased endothelial cell proliferation.

This study investigates how PLA degradation products affect macrophage metabolism and inflammation, showing distinct metabolic responses to amorphous and semi-crystalline PLA.

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

The paper identifies 40 novel genetic loci associated with longitudinal pediatric bone accrual and identifies candidate effector genes through variant-to-gene mapping and functional validation.

The paper uses SPATIaL-seq and ATAC-seq to identify novel effector genes at GWAS loci for bone mineral density by mapping variant-promoter interactions in osteoblasts.

The paper introduces a method to identify candidate genes at GWAS signals by analyzing gene content within topologically associating domains, demonstrating its application to bone mineral density data.