Cell BiologybioRxivPreprint
Dysregulation of replication stress-induced ROS in transformed cell lines: a vicious circle at cancer initiation
Sandrine Ragu, Elodie Dardillac, Sylvain Caillat…·Bernard S. López
This study shows that cancer cell lines exhibit dysregulated LoL-DDR, leading to increased RIR and 8-oxoG accumulation, creating a replication stress-ROS vicious circle that promotes tumorigenesis.
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