Dysregulation of replication stress-induced ROS in transformed cell lines: a vicious circle at cancer initiation
Sandrine Ragu, Elodie Dardillac, Sylvain Caillat, Jean‐Luc Ravanat, Bernard S. López
This study shows that cancer cell lines exhibit dysregulated LoL-DDR, leading to increased RIR and 8-oxoG accumulation, creating a replication stress-ROS vicious circle that promotes tumorigenesis.
bioRxiv · Feb 27, 2025 · PreprintCell Biology