Emma K. Green

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.

This study shows that mice with a germ-line deletion of a Csf1r enhancer lack specific macrophages but maintain normal physiology and can be replenished by donor cells.

A conserved distal element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells.

This study identifies a conserved regulatory element in the mouse Csf1r locus that contributes to transcription in hematopoietic and trophoblast cells, with partial redundancy with other enhancers.

Microglia are not required for normal postnatal brain development and cognitive function in the rat.

This study shows that microglia are not essential for normal postnatal brain development and cognitive function in rats, as Fireko rats lack microglia but show no behavioral differences.

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation in the brain and periphery

This study examines the effects of a loss-of-function mutation in the rat Il34 gene on macrophage development, homeostasis, and inflammation in both the brain and periphery.

Wild type bone marrow-derived microglia-like cells mitigate strain-dependent neuropathology in Csf1r mutant mice.

The paper shows that wild-type bone marrow-derived microglia-like cells reduce strain-dependent neuropathology in Csf1r mutant mice by preventing thalamic calcification.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.