Arashdeep Singh

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

The paper identifies lateralized vagal sensory neurons with distinct roles in satiety and food preference, revealing asymmetrical gut-brain circuits that control feeding behavior.

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

The paper identifies separate vagal reward circuits for fat and sugar that drive overeating when both are activated, even when calorie intake is controlled.

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.