Author

Callum R. Nicoll

University of PaviaORCID 0000-0002-2122-9387Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrea GottingeriD· 3 shared Andrea MatteviiD· 3 shared Domiziana CecchiniiD· 3 shared Marco MalatestaiD· 3 shared Albert J. R. HeckiD· 1 shared Andrea AlfieriiD· 1 shared Annette Seibt· 1 shared Beau James FenneriD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

Andrea GottingerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating

Andrea Gottinger, Marco Malatesta, Callum R. Nicoll, Georg Ansari, Mathieu Quinodoz, Karolina Kamińska, Rachael W. C. Tang, Tien‐En Tan, Beau James Fenner, Pilar Barberán-Martínez, Gema García‐García, José María Millán, Maximilian Pfau, Natalie E Burbach, Domiziana Cecchini, , Andrea Mattevi

This study identifies COQ8 as a chaperone that facilitates coenzyme Q biosynthesis by ATP-driven structural gating of intermediates.

Science Advances · Jul 29, 2026Peer-reviewedBiochemistry

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

Marco Malatesta, Andrea Gottinger, Callum R. Nicoll, Diran Agaid Herebian, Demetra Mattiroli, Domiziana Cecchini, Annette Seibt, Andrea Alfieri, Felix Distelmaier, Andrea Mattevi

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling

Dianzhuo Wang, Andrea Gottinger, Jio Jeong, Callum R. Nicoll, Junlang Liu, Tereza Kadavá, Domiziana Cecchini, Marco Malatesta, Albert J. R. Heck, Andrea Mattevi, Eugene I. Shakhnovich

The paper investigates how metabolon clustering enhances coenzyme Q biosynthesis through substrate channeling using simulations and experiments.

Nature Communications · Jun 29, 2026Peer-reviewedBiophysics