Author

Diran Agaid Herebian

Düsseldorf University HospitalORCID 0000-0002-8528-0122Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:comparative / phylogenetic analysis· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Alessandro PrigioneiD· 2 shared Annette Seibt· 2 shared Ertan MayatepekiD· 2 shared Felix DistelmaieriD· 2 shared Paweł LisowskiiD· 2 shared Agnieszka Rybak‐WolfiD· 1 shared Alberto Pietro PastiiD· 1 shared Andrea AlfieriiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBioengineering

Alessandro PrigioneORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial genome editing reveals the impact of complex I heteroplasmic variants on human neurogenesis

Isabella Tolle, Claudio Fiorini, Jochen Dobner, Annika Zink, Alberto Pietro Pasti, Valeria Balmaceda, Florian Tschuschke, Diran Agaid Herebian, Ertan Mayatepek, Emanuela Bottani, Paweł Lisowski, Valério Carelli, Andrea Rossi, Alessandro Prigione

This study edits mtDNA variants in human iPSCs to show that heteroplasmic complex I variants impair neuronal commitment.

bioRxiv · Oct 31, 2026 · PreprintBioengineering

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

Marco Malatesta, Andrea Gottinger, Callum R. Nicoll, Diran Agaid Herebian, Demetra Mattiroli, Domiziana Cecchini, Annette Seibt, Andrea Alfieri, Felix Distelmaier, Andrea Mattevi

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD

Carolin Angendohr, Christiane Koppe, Diran Agaid Herebian, Anne T. Schneider, Leonie S. Keysberg, Michael T. Singer, Julian Gilljam, Matthias A. Dille, Johannes Georg Bode, Sebastian G. Doll, Marcus Conrad, Mihael Vucur, Tom Luedde

This study investigates whether ACSL4 deletion in liver cells prevents MASLD progression in mice but finds no significant differences compared to wild-type mice.

Hepatology Communications · May 16, 2025Peer-reviewedSystems Biology

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

Carmen Menacho, Satoshi Okawa, Iris Álvarez‐Merz, Annika Wittich, Mikel Muñoz‐Oreja, Paweł Lisowski, Tancredi Massimo Pentimalli, Agnieszka Rybak‐Wolf, Gizem Inak, Shiri Zakin, Mathuravani A. Thevandavakkam, Laura Petersilie, Andrea Zaliani, Barbara Mlody, Annette Seibt, , Alessandro Prigione

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

bioRxiv · Jul 8, 2024 · PreprintNeuroscience