Author

Domiziana Cecchini

University of PaviaORCID 0009-0004-0089-7652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andrea GottingeriD· 4 shared Andrea MatteviiD· 4 shared Callum R. NicolliD· 3 shared Marco MalatestaiD· 3 shared Abhilash JayarajiD· 1 shared Abhishek Kumar· 1 shared Aditya KumariD· 1 shared AkshatKumar NigamiD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

Andrea GottingerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating

Andrea Gottinger, Marco Malatesta, Callum R. Nicoll, Georg Ansari, Mathieu Quinodoz, Karolina Kamińska, Rachael W. C. Tang, Tien‐En Tan, Beau James Fenner, Pilar Barberán-Martínez, Gema García‐García, José María Millán, Maximilian Pfau, Natalie E Burbach, Domiziana Cecchini, , Andrea Mattevi

This study identifies COQ8 as a chaperone that facilitates coenzyme Q biosynthesis by ATP-driven structural gating of intermediates.

Science Advances · Jul 29, 2026Peer-reviewedBiochemistry

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

Marco Malatesta, Andrea Gottinger, Callum R. Nicoll, Diran Agaid Herebian, Demetra Mattiroli, Domiziana Cecchini, Annette Seibt, Andrea Alfieri, Felix Distelmaier, Andrea Mattevi

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling

Dianzhuo Wang, Andrea Gottinger, Jio Jeong, Callum R. Nicoll, Junlang Liu, Tereza Kadavá, Domiziana Cecchini, Marco Malatesta, Albert J. R. Heck, Andrea Mattevi, Eugene I. Shakhnovich

The paper investigates how metabolon clustering enhances coenzyme Q biosynthesis through substrate channeling using simulations and experiments.

Nature Communications · Jun 29, 2026Peer-reviewedBiophysics

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

Domiziana Cecchini, AkshatKumar Nigam, Ming Tang, Joana Reis, Matt Koop, Andrea Gottinger, Callum Robert Nicoll, Yao Wang, Abhilash Jayaraj, Suleyman Selim Cinaroglu, Ricarda Törner, Yehor S. Malets, Minko Gehev, Krishna M. Padmanabha Das, Kelly Churion, , Christoph Gorgulla

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.

bioRxiv · Apr 25, 2023 · PreprintBioinformatics