Lizi M. Hegarty

DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE

This study profiles the gastrointestinal tract over three months post-stroke in an experimental model, showing structural and microbial changes that persist chronically.

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues

This study shows that short fixation times improve macrophage detection in immunofluorescent analysis of mouse and human tissues, without affecting other markers.

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair

This study identifies three subpopulations of colonic macrophages in mice, showing they persist through inflammation and adapt transcriptionally to aid tissue repair.

Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis

The paper identifies inflammation-associated monocytes (IAMs) in IBD and experimental colitis, showing they express ACOD1 to limit cytokine production during inflammation.