Wei Lin

Sensitive and Selective Next-Generation FRET-based PKA Biosensors

The paper introduces AKAR6, a new suite of FRET-based PKA sensors with enhanced sensitivity and selectivity for detecting compartment-specific PKA activity in live cells.

Tardigrade Dsup: Interactions with DNA and protection of cells from oxidative stress

This study uses MD simulations and FLIM-FRET to show Dsup binds DNA in living cells and enhances cell survival under oxidative stress in mammalian and yeast cells.

Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC

The paper introduces a sensitive fluorescent biosensor, ExRai-CKAR2, to study subcellular PKC activity and finds differential regulation of PKC isoforms at the ER, lysosomes, and Par complexes.

Light-gated Integrator for Highlighting Kinase Activity in Living Cells

This paper introduces KINACT, a light-gated tool that converts kinase activity into permanent fluorescent marks for analyzing kinase dynamics and signaling mechanisms.