Matthew D. Sutcliffe

Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

Transcriptomic profiling of mouse mammary tumors enables prognostic and predictive biomarker discovery for human breast cancers

This paper uses mouse mammary tumor data to train machine learning models predicting human breast cancer survival and treatment response.

Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

In situ 10-cell RNA sequencing in tissue and tumor biopsy samples

This paper introduces 10cRNA-seq, an in situ method for sequencing 10 microdissected cells, showing improved sensitivity and reliability compared to scRNA-seq.