Benjamin Dunmore

Interrogation of the glycolytic axis in pulmonary arterial hypertension models and how modifying these can lead to potential therapeutic options.

This paper investigates the glycolytic axis in PAH models and shows that TEPP-46 treatment reduces nuclear PKM2 and improves PAH symptoms in rodent models.

Interleukin-6 is critical in the development of gcn2-mutation associated pulmonary vascular disease in mice

This study shows that interleukin-6 is critical in gcn2-mutation associated pulmonary vascular disease in mice, as its deletion rescues pulmonary hypertension phenotypes.