Mark R. Southwood

YBX3 overexpression in mesothelioma drives aberrant cell proliferation

This study identifies YBX3 as an oncoprotein in mesothelioma that drives cell proliferation through SLC7A5/LAT1-mediated amino acid uptake and shows JPH203 as a potential therapeutic agent.

Interrogation of the glycolytic axis in pulmonary arterial hypertension models and how modifying these can lead to potential therapeutic options.

This paper investigates the glycolytic axis in PAH models and shows that TEPP-46 treatment reduces nuclear PKM2 and improves PAH symptoms in rodent models.

Interleukin-6 is critical in the development of gcn2-mutation associated pulmonary vascular disease in mice

This study shows that interleukin-6 is critical in gcn2-mutation associated pulmonary vascular disease in mice, as its deletion rescues pulmonary hypertension phenotypes.

Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension

This study identifies novel rare genetic variants associated with heritable pulmonary arterial hypertension through whole genome sequencing of cases and controls.