Rodrigo Suárez

Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons

The paper identifies mammalian-specific gene regulatory elements and their role in neocortical neuron subtype diversity and connectivity, linking them to neurodevelopmental disorders.

Polycomb Repressive Complex 2 is critical for mouse cortical glutamatergic neuron development

This study investigates the role of PRC2 in mouse cortical development, finding that homozygous mutations lead to structural and neuronal dysregulation, while heterozygous mutations show distinct effects.

Cortical activity emerges in region-specific patterns during early brain development

The paper investigates early cortical activity patterns in marsupial dunnarts and finds they emerge region-specifically and sequentially before cortical neurogenesis completes.

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation

The paper identifies incomplete interhemispheric fissure remodelling as a key factor in corpus callosum dysgenesis, linking genetic and cellular factors to variable phenotypes in mice and humans.

The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.