Linda J. Richards

The paper examines DNA methylation dynamics in marsupial embryos, finding global demethylation in the trophectoderm but not the embryonic lineage, suggesting 5mC erasure in extraembryonic tissue is ancestral in therian mammals.

The paper presents a model of dynamic spatial and temporal patterning in the embryonic basal ganglia, showing how progenitor movement and transcriptional changes lead to diverse neuronal subtypes.

This study investigates metacognition in individuals with Corpus Callosum Dysgenesis across multiple cohorts and tasks, finding normal perceptual accuracy but reduced metacognitive efficiency.

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

The paper identifies mammalian-specific gene regulatory elements and their role in neocortical neuron subtype diversity and connectivity, linking them to neurodevelopmental disorders.

The paper identifies C12ORF57 as a key regulator of synaptic AMPA currents and excitatory neuronal homeostasis, showing its role in synaptic homeostatic downscaling and its disruption in Temtamy syndrome.

The paper investigates early cortical activity patterns in marsupial dunnarts and finds they emerge region-specifically and sequentially before cortical neurogenesis completes.

The paper shows EMX2 regulates Nfib expression in neural progenitor cells, both activating and repressing it depending on context, which fine-tunes NFI protein levels during cortical development.

The paper identifies incomplete interhemispheric fissure remodelling as a key factor in corpus callosum dysgenesis, linking genetic and cellular factors to variable phenotypes in mice and humans.

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.

This study identifies DDX3X mutations as causing neurodevelopmental disorders by disrupting RNA metabolism and neurogenesis during fetal cortical development.

This study investigates brain network activity in individuals with corpus callosum dysgenesis during cognitive tasks, finding reduced connectivity in the fronto-parietal network with increased task complexity.