Cyril Gitiaux

Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy

The paper identifies dysregulated dsRNA sensing and RNA viral exposure as potential triggers of type I interferon dysregulation in juvenile dermatomyositis onset.

Muscle spatial transcriptomic reveals heterogeneous profiles in untreated juvenile dermatomyositis and the persistence of pathological signature after remission

This study uses spatial transcriptomics to identify persistent pathological signatures in JDM muscle after remission.

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne Muscular Dystrophy

The paper investigates how epigenetic changes in muscle stem cells from Duchenne Muscular Dystrophy patients lead to loss of myogenic identity and identifies MEF2B as a key mediator.

GPATCH11 variants cause mis-splicing and early-onset retinal dystrophy with neurological impairment

This study identifies GPATCH11 variants causing mis-splicing and early-onset retinal dystrophy with neurological impairment through patient analysis, fibroblast studies, and a mouse model.