The paper investigates how epigenetic changes in muscle stem cells from Duchenne Muscular Dystrophy patients lead to loss of myogenic identity and identifies MEF2B as a key mediator.

iScience · Nov 8, 2024Peer-reviewedGenomics

Self-renewing Sox9+ osteochondral stem cells in the postnatal skeleton

Stephanie Farhat, Bahaeddine Tilouche, Spencer Short, Medjie Piron, T. Mark Campbell, José Alex Lourenço Fernandes, Mariya Somyk, Hina Bandukwala, Eric Arezza, Quentin Sastourné-Arrey, Katherine Reilly, Maria Abou Chakra, Gary D. Bader, Leo Kunz, Timm Schroeder, , Daniel L. Coutu

The paper identifies self-renewing osteochondral stem cells in the postnatal skeleton and compares their transcriptomes across adult, fetal, mouse, and human samples.

bioRxiv · Dec 7, 2023 · PreprintDevelopmental Biology

Chromatin reorganization during myoblast differentiation involves the caspase-dependent removal of SATB2

Ryan A. V. Bell, Mohammad H Al-Khalaf, Steve Brunette, Dalal Alsowaida, Alphonse Chu, Hina Bandukwala, Georg Dechant, Galina Apostolova, Francis Jeffrey Dilworth, Lynn A. Megeney

This study shows that SATB2 removal, mediated by caspase 7 cleavage, is critical for chromatin reorganization during myoblast differentiation.

Cells · Mar 11, 2022Peer-reviewedMolecular Biology