Author

James A. Ward

University College DublinORCID 0000-0002-2191-5301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 7 Research Focus:gene regulatory network inference· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:GWAS / association mapping· 3 Assay:whole-genome sequencing· 3 Research Focus:variant calling· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

David Evan MacHughiD· 7 shared Gillian P. McHugoiD· 6 shared Thomas Jonathan HalliD· 5 shared John Arthur BrowneiD· 4 shared Kieran G. MeadeiD· 4 shared Emmeline Wynne HilliD· 3 shared Grace M. O’Gorman· 3 shared Laurent FrantziD· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersGenomics

David Evan MacHughORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genomic status of the Eurasian curlew Numenius arquata : estimating Essential Biodiversity Variables and selection signals for a declining migratory bird

Garrett L. Walsh, ‎Jacob Höglund, Patrik Rödin‐Mörch, James A. Ward, Rebecca C. Örnberg, J.E. Thompson, Declan O’Donovan, Adriaan de Jong, Seán B. A. Kelly, Nicola Hemmings, David Evan MacHugh, Barry John McMahon

The paper analyzes genomic data from Eurasian curlews to assess genetic diversity, population structure, and selection signals in declining populations.

bioRxiv · Aug 28, 2026 · PreprintGenomics

Integrative genomics identifies candidate genes underlying trypanotolerance in hybrid African cattle

Gillian P. McHugo, James A. Ward, Said Ismael Ng’ang’a, Laurent Frantz, John Arthur Browne, Michael Salter‐Townshend, Grace M. O’Gorman, Kieran G. Meade, Emmeline Wynne Hill, Thomas Jonathan Hall, David Evan MacHugh

This study identifies candidate genes for trypanotolerance in African cattle by integrating genomic and transcriptomic data from hybrid populations.

Evolutionary Applications · May 31, 2026Peer-reviewedGenomics

Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues

Gillian P. McHugo, James A. Ward, John Arthur Browne, Grace M. O’Gorman, Kieran G. Meade, Emmeline Wynne Hill, Thomas Jonathan Hall, David Evan MacHugh

This study compares gene expression in trypanotolerant and trypanosusceptible cattle during trypanosome infection across multiple tissues and time points, identifying immune-related and coagulation genes associated with trypanotolerance.

PLoS neglected tropical diseases · Aug 4, 2025Peer-reviewedGenomics

Integrative genomics sheds light on the immunobiology of tuberculosis in cattle

John Francis O'Grady, Gillian P. McHugo, James A. Ward, Thomas Jonathan Hall, Sarah L Faherty O’Donnell, Carolina N. Correia, John A Browne, Michael McDonald, Eamonn P. Gormley, Valentina Riggio, James G. D. Prendergast, Emily L. Clark, Hubert Pausch, Kieran G. Meade, Isobel Claire Gormley, , David Evan MacHugh

This study integrates transcriptomic, genomic, and GWAS data to identify genes and eQTLs associated with the PB transcriptome response to M. bovis infection in cattle.

Communications Biology · Mar 24, 2025Peer-reviewedGenomics

Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations

Gillian P. McHugo, James A. Ward, Said Ismael Ng’ang’a, Laurent Frantz, Michael Salter‐Townshend, Emmeline Wynne Hill, Grace M. O’Gorman, Kieran G. Meade, Thomas Jonathan Hall, David Evan MacHugh

The paper uses local ancestry inference tools to analyze admixture in African and European cattle populations, identifying functional consequences of ancestry on disease resistance and physiological traits.

Heredity · Nov 8, 2024Peer-reviewedGenomics

Genomic Insights into the Population History and Adaptive Traits of Latin American Criollo Cattle

James A. Ward, Said Ismael Ng’ang’a, Imtiaz A. S. Randhawa, Gillian P. McHugo, John Francis O'Grady, Julio M. Flórez, John Arthur Browne, Ana M. Pérez O’Brien, Antonio J. Landaeta-Hernández, José Fernando Garcia, Tad Stewart Sonstegard, Laurent Frantz, Michael Salter‐Townshend, David Evan MacHugh

This study uses whole-genome sequencing and SNP arrays to analyze Criollo cattle from Colombia and Venezuela, revealing African and Asian admixture and selection signatures linked to adaptive traits.

Royal Society Open Science · Mar 1, 2024Peer-reviewedGenomics

Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens

Thomas Jonathan Hall, Gillian P. McHugo, Michael P. Mullen, James A. Ward, Kate E. Killick, John Arthur Browne, Stephen Vincent Gordon, David Evan MacHugh

This study integrates multi-omics data from bovine and human macrophages infected with M. bovis and M. tuberculosis to identify genes and pathways associated with resistance to mycobacterial infection.

Tuberculosis · Dec 2, 2023Peer-reviewedGenomics