John Arthur Browne

Integrative genomics identifies candidate genes underlying trypanotolerance in hybrid African cattle

This study identifies candidate genes for trypanotolerance in African cattle by integrating genomic and transcriptomic data from hybrid populations.

Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming

This study uses multi-omics approaches to analyze how M. bovis infection reprograms the epigenome of bovine alveolar macrophages, identifying key genes and pathways involved in the host response.

A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

The paper develops mRNA-based classifiers using RNA-seq and machine learning to accurately distinguish bTB-positive from bTB-negative cattle and other pathogens.

Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues

This study compares gene expression in trypanotolerant and trypanosusceptible cattle during trypanosome infection across multiple tissues and time points, identifying immune-related and coagulation genes associated with trypanotolerance.

Genomic Insights into the Population History and Adaptive Traits of Latin American Criollo Cattle

This study uses whole-genome sequencing and SNP arrays to analyze Criollo cattle from Colombia and Venezuela, revealing African and Asian admixture and selection signatures linked to adaptive traits.

Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens

This study integrates multi-omics data from bovine and human macrophages infected with M. bovis and M. tuberculosis to identify genes and pathways associated with resistance to mycobacterial infection.

High-resolution transcriptomics of bovine purified protein derivative-stimulated peripheral blood from cattle infected with Mycobacterium bovis across an experimental time course

The paper identifies a 170-gene transcriptional signature in bovine peripheral blood post-M. bovis infection following PPD-b stimulation, suggesting potential biomarkers for bTB diagnostics.

Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria

The paper integrates multi-omics data with genome-wide association results to identify infection response pathways and genomic variants associated with resistance to bovine tuberculosis.

Identification of expression quantitative trait loci in the skeletal muscle of Thoroughbreds reveals heritable variation in expression of genes relevant to cofactor metabolism

This study identifies eQTL in Thoroughbred skeletal muscle, revealing heritable variation in genes related to cofactor metabolism and potential impacts on athletic performance.

The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis

This study examines the DNA methylome of bovine alveolar macrophages infected with Mycobacterium bovis and finds no significant changes in DNA methylation, but identifies genes with intermediate promoter methylation enriched for immune-related functions.

RNA sequencing (RNA-seq) reveals extremely low levels of reticulocyte-derived globin gene transcripts in peripheral blood from horses (Equus caballus) and cattle (Bos taurus)

The paper assesses globin mRNA impact on RNA-seq in horses and cattle, finding low levels that eliminate the need for globin depletion.

Comparative omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli

This study compares the transcriptomic and proteomic profiles of Mycobacterium tuberculosis and Mycobacterium bovis, revealing distinct host responses in bovine macrophages.