YTHDC1 m6A-dependent and m6A-independent functions converge to preserve DNA damage response.
Daniel Elvira-Blázquez, José Miguel Fernández-Justel, Aída Arcas, Luisa Statello, Enrique Goñi, Jovanna González, Benedetta Ricci, Sara Zaccara, Ivan Raimondi, Maite Huarte
This study identifies YTHDC1 as a master regulator of the p53 response through m6A-dependent and -independent mechanisms that affect transcriptional elongation and genomic stability.
The EMBO Journal · Jul 1, 2024Peer-reviewedCancer Biology