Enrique Goñi

This study identifies sin-lncRNA, a long non-coding RNA that regulates mitochondrial metabolism during cellular senescence by modulating oxidative phosphorylation and DLST localization.

The paper introduces ELATUS, a computational framework for detecting functional lncRNAs from scRNA-seq data, showing improved detection and biological relevance compared to traditional methods.

This study identifies YTHDC1 as a master regulator of the p53 response through m6A-dependent and -independent mechanisms that affect transcriptional elongation and genomic stability.

ORC1 binds to cis-transcribed RNAs from genes with replication origins at TSSs, which is required for optimal origin activation.