Author

Sara Zaccara

Columbia University Irving Medical CenterORCID 0000-0002-6569-2015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

Alberto IngaiD· 2 shared Ahwan PandeyiD· 1 shared Alessandro MattèiD· 1 shared Alessandro QuattroneiD· 1 shared Alessandro RomaneliD· 1 shared Alessia MattiviiD· 1 shared Annalisa RossiiD· 1 shared Ben R HawleyiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMolecular Biology

Alberto IngaORCID

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Author profile →

4 papers

Recent·Most cited

Single residues within the YTHDF intrinsically disordered region control m6A-dependent mRNA decay

Benedetta Ricci, Danika Sommer, Daymieri Narvaez, Ruqi Zhang, Jacob B. Geri, Sara Zaccara

This study identifies specific residues in the YTHDF2 IDR that regulate m6A-dependent mRNA decay using base-editor screens.

bioRxiv · Sep 22, 2026 · PreprintSystems Biology

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

Meriem Hadjer Hamadou, Laura Alunno, Tecla Venturelli, Samuel Valentini, Davide Dalfovo, Francesca Lorenzini, Alessia Mattivi, Vincenza Vigorito, Glenda Paola Grupelli, Alessandro Mattè, Pamela Gatto, Michael Pancher, Chiara Valentini, Veronica De Sanctis, Roberto Bertorelli, , Alberto Inga

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

bioRxiv · Apr 2, 2025 · PreprintMolecular Biology

p53-induced apoptosis is specified by a translation program regulated by PCBP2 and DHX30.

Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Matthew D. Galbraith, Zdeněk Andrysík, Ahwan Pandey, Kelly D. Sullivan, Alessandro Quattrone, Joaquin Maximiliano Espinosa, Erik Dassi, Alberto Inga

This study identifies a translational control mechanism regulated by PCBP2 and DHX30 that determines the outcome of p53 activation by Nutlin, shifting the response from cell cycle arrest to apoptosis.

Cell Reports · Mar 1, 2020Peer-reviewedMolecular Biology

Identification of the m6Am methyltransferase PCIF1 reveals the location and functions of m6Am in the transcriptome

Konstantinos Boulias, Diana Toczydłowska-Socha, Ben R Hawley, Noa Liberman, Ken Takashima, Sara Zaccara, Théo Guez, Jean‐Jacques Vasseur, Françoise Debart, Lakshminarayanan Aravind, Samie R. Jaffrey, Eric Lieberman Greer

The paper identifies PCIF1 as the m6Am methyltransferase and develops a method to accurately map m6Am sites, revealing its role in mRNA stability.

Molecular Cell · Jul 3, 2019Peer-reviewedMolecular Biology