The paper identifies synergistic non-neutralizing antibodies against PfRH5 that enhance malaria parasite growth inhibition when combined with neutralizing antibodies.

bioRxiv · Dec 26, 2025 · PreprintImmunology

Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies

Noemi Guerra, Kelly A. Hagadorn, Megha Nair, Laty Gaye Thiam, Barnabas G. Williams, Kirsty McHugh, Dimitra Pipini, Julie Healer, Paul J. Masendycz, Alan F. Cowman, Simon J. Draper, Amy Kristine Bei

This study evaluates the cross-species neutralization potential of monoclonal antibodies against PfCyRPA and PfRIPR against P. knowlesi, finding minimal inhibition despite partial epitope conservation.

bioRxiv · Nov 3, 2025 · PreprintImmunology

Copy number variants underlie the major selective sweeps in insecticide resistance genes in Anopheles arabiensis from Tanzania.

Eric R. Lucas, Sanjay Curtis Nagi, Bilali I. Kabula, Bernard Batengana, William Nhandi Kisinza, Alexander Egyir-Yawson, John Essandoh, Sam Dadzie, Joseph Chabi, Arjèn E. van’t Hof, Emily J. Rippon, Dimitra Pipini, Nicholas J. Harding, Naomi A. Dyer, Chris S. Clarkson, , Martin J. Donnelly

This study identifies copy number variants (CNVs) as key drivers of insecticide resistance in Anopheles arabiensis, revealing new gene clusters and resistance mechanisms to deltamethrin and pirimiphos-methyl.

bioRxiv · Mar 11, 2024 · PreprintGenomics

Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae s.l.

Eric R. Lucas, Sanjay Curtis Nagi, Alexander Egyir-Yawson, John Essandoh, Sam Dadzie, Joseph Chabi, Luc Djogbénou, Adandé A. Medjigbodo, Constant Edi, Guillaume Koffivi Ketoh, Benjamin G. Koudou, Arjèn E. van’t Hof, Emily J. Rippon, Dimitra Pipini, Nicholas J. Harding, , David Weetman

This study identifies novel genetic loci associated with resistance to pyrethroid and organophosphate insecticides in Anopheles gambiae s.l. through genome-wide association analyses.

bioRxiv · Jan 13, 2023 · PreprintGenomics

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

Xavier Grau‐Bové, Eric R. Lucas, Dimitra Pipini, Emily J. Rippon, Arjèn E. van’t Hof, Constant Edi, Samuel Dadzie, Alexander Egyir-Yawson, John Essandoh, Joseph Chabi, Luc Djogbénou, Nicholas J. Harding, Alistair Miles, Dominic P. Kwiatkowski, Martin J. Donnelly, David Weetman

The paper identifies a resistance mechanism to pirimiphos-methyl in Anopheles mosquitoes through duplication and introgression of the Ace1 locus, showing its spread in West Africa.

PLoS Genetics · Jan 21, 2021Peer-reviewedGenomics

Rapid high throughput SYBR green assay for identifying the malaria vectors Anopheles arabiensis, Anopheles coluzzii and Anopheles gambiae s.s. Giles

Joseph Chabi, Arjèn van’t Hof, Louis N'Dri, Alex K. Datsomor, Dora Okyere, Harun Njoroge, Dimitra Pipini, Melinda Patricia Hadi, Dziedzom K. de Souza, Takashi Suzuki, Samuel Dadzie, Helen Pates Jamet

The paper develops a SYBR green real-time PCR assay to distinguish three malaria vector species and their hybrids using melting temperature analysis.

PLoS ONE · Apr 19, 2019Peer-reviewedMolecular Biology