Kirsty McHugh

De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

Structural basis for synergistic antibody protection against the essential malaria invasion complex protein RIPR

The paper identifies synergistic antibody interactions against the malaria protein RIPR, showing how combinations of antibodies targeting specific domains inhibit parasite invasion.

Synergistic non-neutralizing plasma antibodies to PfRH5 drive potent malaria parasite growth inhibition

The paper identifies synergistic non-neutralizing antibodies against PfRH5 that enhance malaria parasite growth inhibition when combined with neutralizing antibodies.

Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies

This study evaluates the cross-species neutralization potential of monoclonal antibodies against PfCyRPA and PfRIPR against P. knowlesi, finding minimal inhibition despite partial epitope conservation.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.