Broad Sarbecovirus Neutralization by an S2-Directed Plasma Antibody Defines a New Site of Vulnerability in SARS-like Viruses
Douglas R. Townsend, Ling Zhou, Michael L. Mallory, William N. Voss, Sean A. Knudson, Cory M. Acreman, John M. Powers, Miranda L. Hubbard, Alexandra Schäfer, Nicholas Catanzaro, David R. Martinez, Sumit Pareek, Connor M. Mullins, Annalee W. Nguyen, Jennifer A. Maynard, , Jason J. Lavinder
The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.
bioRxiv · Jun 8, 2026 · PreprintImmunology