Michael J. Herriges

This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.

This study demonstrates that targeted pre-conditioning and bronchoscopic cell delivery can effectively regenerate airway epithelium in mice, with transplanted cells differentiating into functional lineages.

This paper introduces CoSpar, a computational method that integrates single-cell genomics with lineage tracing to infer cell dynamics, revealing previously undetected fate biases in hematopoiesis, reprogramming, and differentiation.

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

The paper maps cell fate trajectories of human PSC-derived distal lung progenitors using scRNA-seq and identifies developmental plasticity regulated by Wnt signaling.