Alejandro Valenzuela

A phylogenetic protein-coding genome-phenome map of complex traits across 224 primate species.

Cross-species genome-phenome mapping in primates reveals thousands of protein-coding variants linked to the evolution of complex traits.

Why do we get sick? Genetic evidence for evolutionary trade-offs between fertility, longevity, and disease

This study identifies genetic trade-offs between fertility, longevity, and disease risk, showing that disease-risk alleles can persist due to reproductive advantages.

Long-read sequencing reveals two common APOE ϵ3 and ϵ4 intragenic haplotypes in the Spanish population

The paper uses long-read sequencing to identify and characterize APOE haplotypes in a Spanish cohort, finding associations between specific haplotypes and reduced risk of Alzheimer's disease progression.

CAAStools, a toolbox to identify and test Convergent Amino Acid Substitutions.

CAAStools identifies and validates convergent amino acid substitutions in orthologous protein alignments for predefined species groups.

The landscape of tolerated genetic variation in humans and primates

The paper uses primate genetic data to predict human variant pathogenicity with a deep learning classifier trained on 4.3 million common missense variants.

A global catalog of whole-genome diversity from 233 primate species

This study presents whole-genome data from 233 primate species, revealing patterns of genetic diversity, mutation rates, and recurrent missense mutations across primate clades.

Evolutionary constraint and innovation across hundreds of placental mammals

A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.

Variation in predicted COVID-19 risk among lemurs and lorises

The paper analyzes ACE2 gene sequences in strepsirrhine primates to assess their susceptibility to SARS-CoV-2, finding high variability and potential risk in some species.