Hafid Laayouni

Cross-species genome-phenome mapping in primates reveals thousands of protein-coding variants linked to the evolution of complex traits.

This study identifies genetic trade-offs between fertility, longevity, and disease risk, showing that disease-risk alleles can persist due to reproductive advantages.

This study presents a multi-omics analysis of a supercentenarian, revealing that extreme age and poor health are distinct molecular processes.

The paper shows that tissue-specific enhancers are mostly intronic and regulate genes involved in tissue-specific functions, while housekeeping genes are controlled by intergenic enhancers.

The paper analyzes the molecular evolution of human metabolic genes, finding that pathway topology and functional class influence selective pressures, with core genes being more conserved and outer layer genes more plastic.

The paper introduces a regressive alignment algorithm that starts with the most dissimilar sequences, producing more accurate alignments for large datasets.