Julie E. Horvath

The landscape of tolerated genetic variation in humans and primates

The paper uses primate genetic data to predict human variant pathogenicity with a deep learning classifier trained on 4.3 million common missense variants.

A global catalog of whole-genome diversity from 233 primate species

This study presents whole-genome data from 233 primate species, revealing patterns of genetic diversity, mutation rates, and recurrent missense mutations across primate clades.

Variation in predicted COVID-19 risk among lemurs and lorises

The paper analyzes ACE2 gene sequences in strepsirrhine primates to assess their susceptibility to SARS-CoV-2, finding high variability and potential risk in some species.

Rhesus macaques as a tractable physiological model of human ageing

This paper reviews rhesus macaques as a model for human ageing, showing shared gene regulatory signatures in immune ageing between macaques and humans.

Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression

The paper examines how regulatory landscapes influence gene expression stability across mammals, finding that conserved elements and element number are key to expression resilience.