Giedrius Sasnauskas

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

This study shows that viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA by recognizing a signal promoted by viral proteins, enabling broad virus detection without auto-immunity.

This study reveals the structure of the type II-A CRISPR-Cas prespacer selection supercomplex and elucidates the role of Csn2 in Cas9-mediated spacer acquisition.

The paper shows that deoxydinucleotides activate the bacterial anti-phage defense system ApeA by binding to a conserved pocket, enabling broad protection against phage infection.

This paper introduces CROFT-Seq, a method for detecting Cas9 off-target sites in vitro, which is sensitive, rapid, and cost-effective compared to existing methods.

The paper characterizes the CRISPR SAVED-Lon system, showing that filament formation activates protease and ring nuclease activities, leading to growth arrest in E. coli.