Author

Susmita Mandal

Indian Institute of Science Bangalore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Mohit Kumar JollyiD· 4 shared Deepshikha ChandeliD· 2 shared Sarthak SahooiD· 2 shared Srimonta GayeniD· 2 shared Apoorva D. Mavatkar· 1 shared Arpita Guha Neogi· 1 shared Beatriz P. San JuaniD· 1 shared Chandrakala M. Naidu· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersSystems Biology

Mohit Kumar JollyORCID

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5 papers

Recent·Most cited

Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

Sarthak Sahoo, Soundharya Ramu, Madhumathy G Nair, Maalavika Pillai, Beatriz P. San Juan, Heloisa Helena Milioli, Susmita Mandal, Chandrakala M. Naidu, Apoorva D. Mavatkar, Harini Subramaniam, Arpita Guha Neogi, Christine Louise Chaffer, Jyothi S. Prabhu, Jason A. Somarelli, Mohit Kumar Jolly

The paper uses multi-modal transcriptomic data to show basal breast cancer exhibits hybrid epithelial/mesenchymal states and higher phenotypic heterogeneity compared to luminal breast cancer.

bioRxiv · Sep 30, 2023 · PreprintSystems Biology

Transcriptomic-based quantification of the epithelial-hybrid-mesenchymal spectrum across biological contexts

Susmita Mandal, Tanishq Tejaswi, Rohini Janivara, Syamanthak Srikrishnan, Pradipti Thakur, Sarthak Sahoo, Priyanka Chakraborty, Sukhwinder Singh Sohal, Herbert Levine, Jason Thomas George, Mohit Kumar Jolly

The paper compares three transcriptomic metrics to quantify epithelial-mesenchymal plasticity across cancer and non-cancer contexts, finding high concordance and applicability beyond cancer.

Biomolecules · Dec 25, 2021Peer-reviewedBioinformatics

Integrative systems biology approach identified crucial genes and transcription factors associated with gallbladder cancer pathogenesis

Nabanita Roy, Mrinmoy Kshattry, Susmita Mandal, Mohit Kumar Jolly, Dhruba K. Bhattacharyya, Pankaj Barah

This study identifies key genes and transcription factors linked to gallbladder cancer pathogenesis using integrative systems biology approaches and transcriptomic data analysis.

Journal of Clinical Medicine · Aug 10, 2021Peer-reviewedSystems Biology

Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulationembryos

Hemant Chandru Naik, Kishore Hari, Deepshikha Chandel, Susmita Mandal, Mohit Kumar Jolly, Srimonta Gayen

The paper investigates dynamic random monoallelic expression (aRME) in pre-gastrulation embryos, finding that allelic bursting is semi-coordinated rather than independent, leading to expression heterogeneity.

iScience · Aug 5, 2021Peer-reviewedGenetics

Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of chromosome-wide dampening in Naïve Human Pluripotent Stem Cells

Susmita Mandal, Deepshikha Chandel, Harman P. Kaur, Sudeshna Majumdar, Maniteja Arava, Srimonta Gayen

The paper uses single-cell analysis to show partial reactivation of the inactive X-chromosome in naive human pluripotent stem cells, challenging the notion of chromosome-wide dampening.

Stem Cell Reports · Apr 30, 2020Peer-reviewedGenetics