Author

Chenyang Shi

Pacific Northwest National LaboratoryORCID 0000-0002-2274-4305Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

David A. BakeriD· 2 shared Eric M. LynchiD· 2 shared Hao SheniD· 2 shared Justin M. KollmaniD· 2 shared William SheffleriD· 2 shared Chan Johng KimiD· 1 shared Emmanuel DeriveryiD· 1 shared Hua BaiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

David A. BakerORCID

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2 papers

Recent·Most cited

De novo design of inducibly assembling multi-component filaments

Hao Shen, Eric M. Lynch, Noel Jameson, Justin A. Decarreau, Chenyang Shi, Zibo Chen, William Sheffler, Miaomiao Xu, James J. De Yoreo, Jesse G. Zalatan, Justin M. Kollman, David A. Baker

This paper computationally designs multi-component protein filaments that assemble into ordered fibers, validated by cryoEM, and shows regulation via phosphorylation.

bioRxiv · Mar 26, 2025 · PreprintBioengineering

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

Hao Shen, Eric M. Lynch, Chenyang Shi, Joseph L. Watson, Yulai Liu, Ke‐Jia Wu, Hua Bai, Chan Johng Kim, William Sheffler, Emmanuel Derivery, James J De Yoreo, Justin M. Kollman, David A. Baker

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.

bioRxiv · Sep 20, 2024 · PreprintBioengineering