Hao Shen

Programmable De Novo Design of Mesoporous Protein Crystal Frameworks

This paper presents a modular strategy to design programmable, highly porous protein crystals with tunable architectures and composition, enabling applications in catalysis and biomedicine.

De-novo design of a random protein walker

The paper designs and characterizes a random protein walker that diffuses along a designed protein track, finding that walkers with more feet move faster.

De novo design of inducibly assembling multi-component filaments

This paper computationally designs multi-component protein filaments that assemble into ordered fibers, validated by cryoEM, and shows regulation via phosphorylation.

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.

Time-tagged ticker tapes for intracellular recordings

The paper develops a protein-based ticker tape system to record neural activation histories with high temporal resolution.