Chan Johng Kim

De novo design of protease-activatable cytokine prodrugs

This study designs protease-activatable cytokine prodrugs to reduce toxicity while maintaining antitumor efficacy in tumor models.

Potent antitumor activity of a designed interleukin-21 mimic

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.