Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster
Wanhao Chi, Atulya Srisudarshan Ram Iyengar, Monique Albersen, Marjolein Bosma, Nanda M. Verhoeven‐Duif, Chun‐Fang Wu, Xiaoxi Zhuang
This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.
Human Molecular Genetics · Jun 25, 2019Peer-reviewedNeuroscience