Maxx Holmes

Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation

This paper develops sex-specific human electromechanical models to simulate and evaluate sex differences in drug responses and ECG biomarkers, revealing ionic and anatomical mechanisms underlying these differences.

T-World: A highly general computational model of a human ventricular myocyte

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

Calibration and validation strategy for electromechanical cardiac digital twins

This study calibrates and validates ventricular electromechanical models using ECG and pressure-volume biomarkers to assess their credibility for cardiac Digital Twin applications.