Jakub Tomek

Precision Targeting of Troponin I Phosphorylation Prevents Diastolic Dysfunction while Preserving Systolic Performance

This paper identifies a nanodomain mechanism regulating troponin I phosphorylation and demonstrates a peptide that selectively enhances relaxation without compromising systolic function in heart failure.

Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation

This paper develops sex-specific human electromechanical models to simulate and evaluate sex differences in drug responses and ECG biomarkers, revealing ionic and anatomical mechanisms underlying these differences.

T-World: A highly general computational model of a human ventricular myocyte

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

A ‘comb’ algorithm for accurate detection of calcium transients and action potentials in regularly activating cardiac preparations

The paper introduces a comb algorithm to accurately detect calcium transients and action potentials in cardiac data with regular activation patterns.