Sahaana Chandran

This study identifies how chromatin structure heterogeneity in B-ALL correlates with transcriptional subtypes and developmental stages, revealing its role in disease progression.

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

The paper develops sn-m3C-seq to profile chromatin conformation and DNA methylation in single nuclei, enabling high-resolution cell-type classification and chromatin map reconstruction in mice.