Author

Young Sun Lee

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6612-7341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Charles L. SawyersiD· 2 shared Agnieszka ChryplewicziD· 1 shared An Nguyen· 1 shared Anuradha GopalaniD· 1 shared Arun A. Chandrakumar· 1 shared Ben DoroniD· 1 shared Bradley A. StohriD· 1 shared Brett Stewart CarveriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Charles L. SawyersORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

Young Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz, Max Land, Roshan Sharma, Joseph Chan, Perianne Smith, Sanjay V. Kottapalli, Linda E. Fong, Zhenghao Chen, Eric Huttenlocher Bent, HuiYong Zhao, Elisa de Stanchina, Wenfei Kang, Shevin Narine, , Charles L. Sawyers

This study identifies an IL-1β/IL-6 signaling circuit in the tumor microenvironment that drives prostate cancer progression from pre-invasive to invasive stages.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

Reconstructing tumor evolution without chromosomal instability reveals in vivo determinants of therapeutic response

Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B Hoelscher, Valbona Luga, Arun A. Chandrakumar, Lore Hoes, Junghwa Cha, Young Sun Lee, Katelyn Herm, Ben Doron, Danika Bakke, Sharon Wu, C.K. Cornelia Ding, Bradley A. Stohr, , Rohit Bose

This study develops an in vivo platform called SETs to reconstruct tumor evolution without chromosomal instability, identifying therapeutic response determinants in prostate cancer.

bioRxiv · Mar 17, 2025 · PreprintCancer Biology