Zhenghao Chen

Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.

This study identifies an IL-1β/IL-6 signaling circuit in the tumor microenvironment that drives prostate cancer progression from pre-invasive to invasive stages.

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

Vector2Variant transforms high-dimensional data into genome-wide association scans without predefined phenotypes, identifying genetic associations and novel variants linked to diseases.

The paper analyzes longitudinal body weight data in mice to identify traits linked to lifespan, finding heritable traits associated with energy homeostasis and longevity.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Baikal improves fluorescence microscopy image denoising using diffusion models without requiring paired noisy and clean images.

This study develops a high-dimensional phenotyping platform to evaluate physiological aging and resilience in mice, finding that aging begins early and resilience declines with age.