Author

Ximena Zottig

Howard Hughes Medical InstituteORCID 0000-0002-2344-5163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Nikolaus GrigorieffiD· 4 shared Andrei A. KorosteleviD· 2 shared Chun-Ying HuangiD· 2 shared Johannes ElferichiD· 2 shared Lingli KongiD· 2 shared Zahra SerajiD· 2 shared A.B. LovelandiD· 1 shared Emily SholiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

Nikolaus GrigorieffORCID

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4 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 24, 2026

Structural basis for start codon selection by eIF5-mimic proteins

Ximena Zottig, Chun-Ying Huang, Zahra Seraj…·Andrei A. Korostelev

This study reveals how eIF5-mimic proteins regulate start codon selection through structural insights from cryo-EM and biochemical assays.

2 citations

protein structureexperimental assay

𝕏 PostBluesky

BiophysicseLifePeer-reviewedApr 30, 2026

Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

Lingli Kong, Ximena Zottig, Johannes Elferich, Nikolaus Grigorieff

Unbend improves cryo-EM image correction by addressing localized sample motion with a 3D spline model, enhancing signal-to-noise ratio and particle detection.

DOI 10.7554/elife.109119.3

cryo-EMdeep learning

𝕏 PostBluesky

Molecular BiologybioRxivNov 25, 2025

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

Zahra Seraj, Ximena Zottig, Chun-Ying Huang…·Andrei A. Korostelev

The paper uses in extracto cryo-EM to study ribosome hibernation factors, finding eEF2 as the most abundant hibernation factor bound to 60S and 80S ribosomes.

1 citation

humannon-human primate

𝕏 PostBluesky

BiophysicseLifePeer-reviewedMay 1, 2024

CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples

Johannes Elferich, Lingli Kong, Ximena Zottig, Nikolaus Grigorieff

CTFFIND5 improves CTF estimation by incorporating sample thickness and tilt, enhancing cryoEM image quality assessment.

40 citationstop 2%

cryo-EMdeep learning

𝕏 PostBluesky