Author

Josimar Macedo de Castro

Universidade Federal do Rio Grande do SulORCID 0000-0002-2354-9704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Algemir Lunardi BrunettoiD· 1 shared Andre Tesainer BrunettoiD· 1 shared Bruna Almeida dos SantosiD· 1 shared Caroline Brunetto de FariasiD· 1 shared Lauro José GregianiniD· 1 shared Lívia FratiniiD· 1 shared Luís Fernando da Rosa RiveroiD· 1 shared Marcelo A. C. FernandesiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Algemir Lunardi BrunettoORCID

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1 paper

Recent·Most cited

Delayed growth of Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1R

Bruna Almeida dos Santos, Natália Hogetop Freire, Lívia Fratini, Matheus Dalmolin, Josimar Macedo de Castro, Marcelo A. C. Fernandes, Lauro José Gregianin, Andre Tesainer Brunetto, Algemir Lunardi Brunetto, Luís Fernando da Rosa Rivero, Mariane da Cunha Jaeger, Rafael Roesler, Caroline Brunetto de Farias

The paper shows that K252a treatment delays Ewing sarcoma tumor growth and reduces Trk, PI3K, and IGF1R expression and activity, with combined treatment more effective than single agents.

bioRxiv · Oct 23, 2025 · PreprintCancer Biology