GroEL/ES Buffers Entropic Traps In Folding Pathway During Evolution Of A Model Substrate
Anwar Sadat, Satyam Tiwari, Kanika Verma, Arjun Ray, Mudassar Ali, Vaibhav Upadhyay, Anupam Singh, Aseem Chaphalkar, Asmita Ghosh, Rahul Chakraborty, Kausik Chakraborty, Koyeli Mapa
The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.
Journal of Molecular Biology · Aug 21, 2020Peer-reviewedMolecular Biology