Mudassar Ali

This study identifies the N-terminal segment of ANKZF1 as a negative regulator of its mitochondrial targeting, revealing an internal mitochondrial signal and structural changes that enable mitochondrial localization.

This study identifies ANKZF1 as a key player in PINK1-Parkin-mediated mitophagy, showing its role in eliminating stress-damaged mitochondria through LC3 interaction.

The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.