Iain P. Chessell

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

This study evaluates three potential treatments for cancer-induced bone pain in mice, finding that dual inhibition of NGF and TNF significantly reduces pain-related behaviors.

This study shows TNFα sensitizes colonic nociceptors via TNFR1 and p38 MAPK, enhancing responses to capsaicin and noxious distension.

The DPUK Data Portal provides secure access to cohort data for dementia research, supporting multi-modal analyses and collaborations across multiple institutions.