Ezequiel Calvo-Roitberg

The paper identifies RNA as the molecular glue forming a stable chromatin compartment associated with nuclear speckles, independent of speckles themselves.

CRYPTID-exon identifies cryptic exons in human RNA-seq data, showing their impact on mRNA stability and gene expression through ASO targeting.

SPARK generates simulated nascent RNA sequencing data to benchmark computational tools for analyzing transcriptional dynamics.

The paper identifies a spatial coordination between mRNA initiation and termination sites, proposing a 'Positional Initiation-Termination Axis' that influences isoform diversity.

This paper evaluates the accuracy of identifying mRNA transcript start and end sites from long-read sequencing data and introduces a method to improve terminal end identification.

The paper estimates genome-wide 3' end cleavage rates using metabolic labeling, sequencing, and modeling, finding fast but variable cleavage with associations to sequence elements and RNA Polymerase II localization.

The paper analyzes circular ANRIL isoforms in human pancreatic islets and finds higher circular:linear ANRIL ratios in T2D risk allele carriers, linked to reduced beta cell proliferation.

The paper identifies hybrid internal-terminal exons in human transcriptomes using a new pipeline and shows their tissue-specific usage and association with RNA splicing genes.