Michael P. McGurk

The paper shows that the strength of a gene's first 5' splice site determines its expression level through intron-mediated enhancement, independent of 3' splice site strength.

The paper identifies two major classes of 5' splice sites regulated by LUC7 proteins in animals and plants, showing conserved function across species.

This study identifies sequence features that determine intron-mediated enhancement by analyzing thousands of synthetic introns in human cells.

KATMAP infers splicing factor activity and regulatory targets from knockdown data by modeling splicing changes and predicting SF regulation at individual exons.

RBPamp models protein-RNA interactions using RBNS data to predict in vivo binding affinities and eCLIP densities for 79 human RBPs.

The paper identifies hybrid internal-terminal exons in human transcriptomes using a new pipeline and shows their tissue-specific usage and association with RNA splicing genes.

The paper investigates piRNA regulation in Drosophila by analyzing transposable element clade evolution and finds that younger clades are associated with higher antisense piRNA abundance.

The paper analyzes HTT transposable element dynamics in Drosophila telomeres, finding that their variation is driven by telomere instability rather than genetic conflict.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

The paper identifies tandem transposable element dimers in Drosophila genomes and shows they can serve as precursors for satellite DNA formation.