Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2
Peter R. McIlroy, Wendy M. Zinzow-Kramer, Madison Leigh Ellis…·Matthew Charles Woodruff
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4 papers
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Peter R. McIlroy, Wendy M. Zinzow-Kramer, Madison Leigh Ellis…·Matthew Charles Woodruff
Wynton D. McClary, John Z. Chen, Hui Wang…·Alana Gerhardt
This paper demonstrates the successful spray drying of a replicon-NLC vaccine against H5N1 avian influenza, maintaining stability and immunogenicity for up to 3 months at 4°C.
Wynton D. McClary, Devin S. Brandt, Madeleine F. Jennewein…·Emily A. Voigt
This paper develops a replicon vaccine against H5N1 influenza that can be administered intranasally or intramuscularly, showing efficacy in reducing morbidity and mortality in a ferret model.
Matthew Ykema, Michael A. Davis, Darshan N. Kasal…·Emily A. Voigt
An intranasal self-amplifying RNA vaccine delivered via nanostructured lipid carriers induces mucosal immunity and protects against H5N1 and H7N9 influenza in ferrets.