Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2
Peter R. McIlroy, Wendy M. Zinzow-Kramer, Madison Leigh Ellis…·Matthew Charles Woodruff
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6 papers
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Peter R. McIlroy, Wendy M. Zinzow-Kramer, Madison Leigh Ellis…·Matthew Charles Woodruff
Emily A. Voigt, Anas Alsharaydeh, Darshan N. Kasal…·Christopher B. Fox
This study evaluates a TB vaccine candidate, ID93 + GLA-3M-052-LS, showing enhanced mucosal and systemic immunity and protection against Mtb in BCG-primed mice.
Wynton D. McClary, John Z. Chen, Hui Wang…·Alana Gerhardt
This paper demonstrates the successful spray drying of a replicon-NLC vaccine against H5N1 avian influenza, maintaining stability and immunogenicity for up to 3 months at 4°C.
Peter Battisti, Matthew Ykema, Darshan N. Kasal…·Emily A. Voigt
This paper develops a bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses, showing it induces robust immune responses and complete protection in animal models.
Wynton D. McClary, Devin S. Brandt, Madeleine F. Jennewein…·Emily A. Voigt
This paper develops a replicon vaccine against H5N1 influenza that can be administered intranasally or intramuscularly, showing efficacy in reducing morbidity and mortality in a ferret model.
Matthew Ykema, Michael A. Davis, Darshan N. Kasal…·Emily A. Voigt
An intranasal self-amplifying RNA vaccine delivered via nanostructured lipid carriers induces mucosal immunity and protects against H5N1 and H7N9 influenza in ferrets.